EFFICACY OF LYCOPENE ON AFLATOXIN B1- INDUCES OXIDATIVE STRESS, HEPATOTOXICITY, APOPTOSIS AND IMMUNODEFICIENCY IN JAPANESE QUAIL

Mycotoxins are harmful auxiliary metabolites delivered by species of filamentous organisms developing on grains some time recently collect and in capacity. The study was planned to evaluate the protective role lycopene (LYC) against Aflatoxin B1 (AFB1) induces oxidative stress, hepatic toxicity, apoptosis Japanese quail. Sixty quail chicks (three-week-old) were randomly allocated into four groups; Negative control group; -B1 group (1 mg/kg feed) as positive control; supplemented (200 AFB1 with mg/kg). growth performance parameters, serum biochemical indices, liver antioxidant activities well histopathological studies, immunohistochemical pictures performed. results showed a significant increase decrease feed conversion ratio (FCR) aflatoxin inclusion group. Moreover, enzymes (ALT, AST, ALP) significantly (P < 0.05) decreased. In addition, malondialdehyde (MDA) levels decreased, while superoxide dismutase (SOD), Glutathione peroxidase (GSH-Px) catalase (CAT) increased tissues. Furthermore, when compared aflatoxin-inclusion had improved tissue lower cytokine production (IL-6 TNF-). conclusion, these findings implied that dietary administration has alleviated AFB1-triggered inflammatory response